High-affinity choline transporter 1
Web1 de mai. de 1990 · It is demonstrated that these two affinity states of [3H]HC‐3 binding are totally interconvertible; addition of 0.1 mM ATP in the binding assay medium … Web1 de out. de 2014 · The high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and… Expand 15 PDF Competitive inhibition of the high-affinity choline transporter by tetrahydropyrimidine anthelmintics.
High-affinity choline transporter 1
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WebThe molecular entity for the high-affinity choline transporter was identified and is designated CHT1, which mediates Na+- and Cl−-dependent choline uptake with high sensitivity to hemicholinium-3 and has been characterized both at the molecular and functional levels. The cholinergic neurons have long been a model for biochemical … Web1 de jan. de 2024 · The high-affinity choline transporter was first cloned in 2000 and designated as CHT1 (Okuda et al. 2000 ). Structure and Functional Properties of CHT1 CHT1 is a member of the solute carrier family 5 (SLC5, sodium/glucose cotransporter family) and is also known as SLC5A7. It shares 20–25% amino acid sequence homology with …
Web1 de mai. de 2003 · 1. High-affinity choline transporters (CHTs) have been attributed to CHT1 (also known as SLC5A7), which has a Km of 0.5–5 μM for choline. CHT1 is … WebThe high-affinity choline transporter (CHT1), which is specifically expressed in cholinergic neurons, constitutes a rate-limiting step for acetylcholine synthesis. We have found that …
Web10 de jul. de 2015 · Synthesis and release of the neurotransmitter acetylcholine (ACh) is closely linked to the activity of the high-affinity choline transporter protein (CHT), but the impact of insulin receptor signaling and neuronal insulin resistance on these aspects of cholinergic function are unknown. WebComponents. integral component of membrane / neuronal cell body / plasma membrane. General Function. Choline:sodium symporter activity. Specific Function. Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent.
Web29 de jul. de 2014 · Highaffinity choline transporter 1 is involved in choline transport from the extracellular space to the neuron (48). Innexin 2 is required for the regulation of neuronal networks (49)....
WebLOC799259 high-affinity choline transporter 1-like [ (zebrafish)] Gene ID: 799259, updated on 4-Nov-2024. north dakota medicaid directorWebProtein target information for High affinity choline transporter 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay … how to resize smartart in wordWeb22 de jul. de 2024 · The first transporter is high-affinity choline transporter 1 (CHT1) that is expressed in cholinergic neurons and is linked to acetylcholine synthesis, which has a … north dakota medicaid billing softwareWeb1 de mar. de 2007 · Cholinergic innervation of the heart has been analyzed using cholinergic markers including acetylcholinesterase, choline acetyltransferase (ChAT), and vesicular acetylcholine transporter (VAChT). In the present study we demonstrate putative cholinergic nerves in the rat heart using an antibody to ChAT of a peripheral type … north dakota med aideWeb13 de abr. de 2024 · The four GATs identified in humans are GAT1 (SLC6A1), GAT2 (SLC6A13), GAT3 (SLC6A11), and betaine/GABA transporter-1 BGT-1 (SLC6A12 ... ammonium, and choline does not trigger GABA transport in GAT1 ... Neuronal, glial, and epithelial localization of gamma-aminobutyric acid transporter 2, a high-affinity gamma … north dakota medicaidWeb1 de mai. de 1990 · It is demonstrated that these two affinity states of [3H]HC‐3 binding are totally interconvertible; addition of 0.1 mM ATP in the binding assay medium quantitatively converted all the binding sites to the low‐affinity state, whereas addition of 1 mM β,γ‐methylene 5′‐ATP quantitatively Conversion of all thebinding sites toThe … north dakota medicaid estate recoveryWebThe transporter protein was cloned and identified by Okuda and co-workers in 2000, and shown to exhibit high-affinity, sodium-dependent choline uptake ( Km ~2 μM) which … how to resize slicer in excel