Chromopyrrolic acid
WebJan 1, 2006 · Chromopyrrolic acid is oxidized by six electrons compared to the starting pair of L-tryptophan molecules. RebO is an L-tryptophan oxidase flavoprotein and RebD … WebMay 1, 2015 · We provide the first experimental evidence for intermediates being involved in catalysis by RebD in generating the chromopyrrolic acid (CPA) scaffold of …
Chromopyrrolic acid
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WebApr 24, 2009 · Chromopyrrolic acid 11 is a shunt product and not a precursor to violacein (Balibar and Walsh, 2006, Sánchez et al., 2006a). A filtration-HPLC assay established that VioE, the next enzyme in the pathway, acts on an as yet uncharacterized intermediate produced by VioB to generate prodeoxyviolacein 19 (Balibar and Walsh, 2006). WebDichlorochromopyrrolate synthase ( EC 1.21.3.9, RebD, dichlorochromopyrrolic acid synthase) is an enzyme with systematic name 2-imino-3- (7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming). [1] [2] This enzyme catalyses the following chemical reaction 4 2-imino-3- (7-chloroindol-3-yl)propanoate + O 2
WebDec 29, 2004 · The following compounds were purified from S. albus harboring the plasmids mentioned in brackets: chromopyrrolic acid 1 (pCS014), K-252c or staurosporine aglycone 3 (pCS039), 11-chlorochromopyrrolic acid 7 (pCS018), 1-chloroarcyriaflavin 9 (pCS020), 9-chlorochromopyrrolic acid 21 (pCS049) and 3-chloroarcyriaflavin 23 (pCS037). Webchlorination of chromopyrrolic acid or arcyriaflavin was detected when we fed either of these compounds to a S. albus strain expressing rebH. In contrast, coexpression of rebODH or rebOD-CPH yielded chloro and dichloro versions of chromopyrrolic acid (compounds 7 and 10), A S. albus andA ...
WebSep 25, 2007 · The minor peaks indicate that, at low levels, chromopyrrolic acid spontaneously degrades under aerobic conditions at room temperature. This result … WebMay 20, 2009 · Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; …
WebApr 16, 2009 · Figure 1. Chromatogram showing baseline resolution of the 13 alcohols in the order listed in Table 1. Chromatographic conditions: 6 ft (∼180 cm)×2 mm ID glass …
WebIndole-3-pyruvic acid can be used: As a precursor for the synthesis of chromopyrrolic acid by a heme-containing enzyme.As a reactant in the Biginelli-like scaffold syntheses. Packaging. 1, 5 g in poly bottle. Linkage. α-Keto analogue … iphone 13 battery health after 6 monthsWebMay 20, 2024 · 多环特特拉姆酸大环内酰胺(polycyclic tetramate macrolactams，PTMs)是一类母核结构经PKS-NRPS杂合途径生物合成由特特拉姆酸(tetramic acid)结构和多环体系(常为2～3环)构成的内酰胺类化合物，具备抗肿瘤、抗细菌、抗真菌等生物活性[74].Hou等[75]前期通过培养条件优化的策略 ... iphone 13 battery extenderWebMolecules 2024, 25, 256 8 of 16 Gene expression elucidated that 3 is solely required by the tetrameric hemoprotein StaD or RebD for the production of the chromopyrrolic acid 4 in staurosporine or rebeccamycin biosynthesis [45,49], contrary to the previous reports that both 2 and 3 are the precursors for the coupling reaction to yield 4 [38,45]. iphone 13 battery issuesWebJun 12, 2014 · The chemical structure was determined to be 3,4.di.(3-indolyl)-pyrrole 2,5-dicarboxylic acid on the bases of 1 H- and 13 C-NMR spectra, and MS data. This compound was named chromopyrrolic acid, and was also detected in the various metabolites produced by the parent strain, although the amount produced was somewhat smaller. iphone 13 battery packWebchromopyrrolic acid for indolocarbazole biosynthesis, whereas VioE transforms compound X into protodeoxyviolaceinic acid, which is further modified by other enzymes to produce viola-cein. Thus, VioE plays a key role in the construction of the molecular skeleton of violacein. Here, we present the crystal iphone 13 battery percentWebChromopyrrolic Acid. Chromopyrrolic acid (55) formation is catalyzed by the chromopyrrolic acid synthase ClaD. From: The Alkaloids: Chemistry and Biology, … iphone 13 battery dies fastWebApr 5, 2012 · The indolocarbazole biosynthetic enzymes StaC, InkE, RebC, and AtmC mediate the degree of oxidation of chromopyrrolic acid on route to the natural products staurosporine, K252a, rebeccamycin, and AT2433-A1, respectively. iphone 13 battery pack case